Game-Theoretic Approach to Tourism Supply Chain Coordination under Demand Uncertainty For Package Holidays

Demand uncertainty is one of the most significant characteristics of the tourism industry. In a typical tourism supply chain (TSC) for package holidays, multiple tour operators reserve rooms from a hotel chain in advance according to their demand predictions. Discrepancies between demand predictions and actual demand lead to shortages or unused room reservations, which inevitably leads to reduced profits for the tour operators concerned. This article examines different TSC coordination strategies to determine how they can be used to help alleviate such negative effects. A game-theoretic approach is used to analyze the different coordination relationships between TSC players. Two coordination programs are discussed. The first is a horizontal coordination program in which tour operators exchange shortages or unused reservations with each other. The second is a vertical coordination program in which tour operators trade shortages or unused reservations with hotel chains. Game models are established and analyzed for the two coordination strategies and uncoordinated conditions, respectively. The analytical results suggest that both coordination strategies can be used to reduce the negative impacts of the demand uncertainty. The results also show that the horizontal coordination is preferred to the vertical coordination when the competition among tour operators is fierce.published_or_final_versio

Strategy choice in tourism supply chains for package holidays: a game-theoretic approach

Enterprises in a tourism supply chain usually adopt and operate two business strategies: maximizing their profits or their revenues. This paper investigates the conditions on which these strategies allow enterprises to achieve the maximum benefits in the context of entire supply chain. Several managerial implications have been derived from this theoretical research. Firstly, theme park operator, tour operators and hotel & accommodation providers obtain larger market shares and profits if they select the revenue maximization (R) strategy. Secondly, the profit maximization (P) strategy is a better strategy for both sectors when all the tour operators and all hotel & accommodation providers choose the same strategy. Finally, if both sectors could freely choose their strategies, there is market equilibrium where P-strategy and R-strategy could coexist.published_or_final_versio

Involvement of macrophage migration inhibitory factor (MIF) in graft-versus-host disease (GvHD)

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Elevation of marcophage migration inhibitory factor level acute myocardial infarction but not in acute myocardial ischaemia

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microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway

microRNA-29b (miR-29b) is known to be associated with TGF-β-mediated fibrosis, but the mechanistic action of miR-29b in liver fibrosis remains unclear and is warranted for investigation. We found that miR-29b was significantly downregulated in human and mice fibrotic liver tissues and in primary activated HSCs. miR-29b downregulation was directly mediated by Smad3 through binding to the promoter of miR-29b in hepatic stellate cell (HSC) line LX1, whilst miR-29b could in turn suppress Smad3 expression. miR-29b transduction in the liver of mice prevented CCl4 induced-fibrogenesis, concomitant with decreased expression of α-SMA, collagen I and TIMP-1. Ectopic expression of miR-29b in activated HSCs (LX-1, HSC-T6) inhibited cell viability and colony formation, and caused cell cycle arrest in G1 phase by downregulating cyclin D1 and p21cip1. Further, miR-29b induced apoptosis in HSCs mediated by caspase-9 and PARP. miR-29b inhibited its downstream effectors of PIK3R1 and AKT3 through direct targeting their 3'UTR regions. Moreover, knockdown of PIK3R1 or AKT3 suppressed α-SMA and collagen I and induced apoptosis in both HSCs and in mice. In conclusion, miR-29b prevents liver fibrogenesis by inhibiting HSC activation and inducing HSC apoptosis through inhibiting PI3K/AKT pathway. These results provide novel mechanistic insights for the anti-fibrotic effect of miR-29b.published_or_final_versio

Progenitor-like cells derived from mouse kidney protect against renal fibrosis in a remnant kidney model via decreased endothelial mesenchymal transition

Showing A quantification of GFP-positive cells in the lung after intravenous injection of MKPCs in five-sixths nephrectomized mice (y axis shows the number of cells, while the x axis (FL1-H) shows the fluorescence intensity; M1 is the area of GFP-positive cells) and B immunohistochemistry of the lung after intravenous injection of MKPCs into a mouse that underwent five-sixths nephrectomy. Few GFP positive cells were found in the lung at the first day but there were no GFP-positive cells at week 14. (TIFF 2253 kb

A survey on health-promoting lifestyle among community-dwelling older people with hypertension in Macau

2007-2008 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

The Influence of Posture, Applied Force and Perturbation Direction on Hip Joint Viscoelasticity.

Limb viscoelasticity is a critical neuromechanical factor used to regulate the interaction with the environment. It plays a key role in modelling human sensorimotor control, and can be used to assess the condition of healthy and neurologically affected individuals. This paper reports the estimation of hip joint viscoelasticity during voluntary force control using a novel device that applies a leg displacement without constraining the hip joint. The influence of hip angle, applied limb force and perturbation direction on the stiffness and viscosity values was studied in ten subjects. No difference was detected in the hip joint stiffness between the dominant and non-dominant legs, but a small dependency was observed on the perturbation direction. Both hip stiffness and viscosity increased monotonically with the applied force magnitude, with posture being observed to have a slight influence. These results are in line with previous measurements carried out on upper limbs, and can be used as a baseline for lower limb movement simulation and further neuromechanical investigations